Stef Foster and Lena Adams, a lesbian couple, have a family of adopted, biological, and foster children. Mariana and Jesus are adopted 15-year-old twins and Brandon is Stef's 16-year-old biological son from a previous marriage. Everything is going fine in the house until Callie and Jude arrive. 16-year-old Callie and her 12-year-old brother Jude have been in many different foster homes, but when they are placed with the Fosters, things begin to happen. In this series, the Fosters will deal with many different issues: hook-ups, break-ups, romances, and important life lessons.

Follows Lia Haddock, a journalist for American Public Radio (APR), as she unravels the mystery behind the disappearance of over 300 people at a neuroscience research facility in Tennessee.

Three siblings who move into their ancestral estate after their father's gruesome murder discover their new home's magical keys, which must be used in their stand against an evil creature who wants the keys and their powers.